Locus I
£45.00
This locus influences pheomelanin, the red pigment in coat colour. A mutation in the MFSD12 gene dilutes pheomelanin without affecting eumelanin, so black areas stay black while red areas fade to cream or white. The intensity can vary.
Locus I (Intensity locus)
The I locus influences the intensity of pheomelanin (red/yellow pigment).
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i = recessive mutation in the MFSD12 gene
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Dogs with i/i genotype show diluted pheomelanin
– dark red becomes cream or white -
It does not affect eumelanin
– black areas remain black -
The degree of lightening can vary between individuals
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This mutation does not cause albinism, because nose, eye and skin pigmentation remain normal
Inheritance:
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Recessive → a dog must inherit two copies (i/i) for the diluted colour to appear
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Carriers (I/i) look normal but can pass the mutation to their offspring
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